The center, originally named Frontier Research Center, was established in 1998 as a core facility to promote the Frontier Research Project supported by the Ministry of Education, Culture, Sports, Science and Technology. This project, carried out for a period of 10 years, facilitated various lines of research and interdisciplinary interaction in this institution. In recognition of its scientific achievement, a new project was set by the Ministry in 2008, and the center was renamed Advanced Science Research Center.
Notable thesis includes…
１. Takagi, Y., Setoyama, D., Ito, R., Kamiya, H., Yamagata, Y., Sekiguchi, M. Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates COMPARISON WITH MTH1 AND MTH2. J. Biol. Chem., 287, 21541-21549 (2012)
２. Lim, T. H., Fujikane, R., Sano, S., Sakagami, R., Nakatsu, Y., Tsuzuki, T., Sekiguchi, M., Hidaka, M. Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA. DNA Repair, 11, 259-266 (2012)
３. Shichita, T., Hasegawa, E., Kimura, A., Morita, R., Sakaguchi, R., Takada, I., Sekiya, T., Ooboshi, H., Kitazono, T., Yanagawa, T., Ishii, T., Takahashi, H., Mori, S., Nishibori, M., Kuroda, K., Akira, S., Miyake, K., Yoshimura, A. Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med, 18, 911-917 (2012)
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