Periodontitis and oral cancer causing bone loss and bone weakening have been increasing especially among elderly people. It is, however, very difficult for the aged to reconstruct the osseous tissue in the oral area because the tooth loss causes an irreversible rapid bone atrophy and high risk bacterial infection due to less ductility of the epithelium tissue. In this project, we aim to establish the reconstruction system mainly working on three following themes.
1) Development of novel carbonate apatite-based materials and bioactive glasses with higher osteoconductivity
2) Development of DNA/Polycation based membrane enable protection against infection
3) Development of gel sheet containing light-stimulating molecular heater (Carbon nanotube, CNT)
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