Professor, Department head
Section of Biochemistry
Department of Functional Bioscience
Division of Biomedical Sciences

 1986 D.D.S. School of Dentistry, Kyushu University
 1990 Ph.D. Graduate School of Dentistry, Kyushu University
 1991- Postdoctoral Fellow, Harvard Medical School
 1995- Assistant Professor, Nara Institute of Science and Technology
 2006- Professor, Section of Biochemistry, Fukuoka Dental College

 The focus of our current studies is on understanding the roles of homologous recombination in mitotic cells, that is, how homologous recombination contributes to genome maintenance and how it is regulated in a way to suppress genome instability. My interests in the subject have grown through my experiences of studying molecular mechanisms of homologous recombination in the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, using both biochemical and molecular genetic approaches. These studies have led me to be interested in the effects of recombination on chromosome aberration. The molecular analysis of chromosome aberration in Saccharomyces cerevisiae revealed that homologous recombination plays both positive and negative roles in the maintenance of genome stability and is regulated at multiple steps in such a way as to suppress genome instability. Our goal is to understand the molecular mechanism to control its dual roles. An underlying assumption in our studies is that a detailed understanding of genome maintenance in yeast will give us a picture of how the process works in mammals and hence insights to understand genome instability in cancer development and aging.

1.Controls of homologous recombination in genome maintenance
2.Molecular mechanisms leading to chromosome aberration
3.Genome rearrangements induced by oxdative stress

Research work by UMEZU Keiko