IKEBE Tetsuro, DDS Ph.D

Professor, Department head
Section of Oral Surgery
Department of Oral and Maxillofacial Surgery
Division of Oral & Medical Management

 Dr. Tetsuro IKEBE graduated from the Faculty of Dentistry, Kyushu University in 1984 and continued in Ph.D. course of the university, studying on the effects of inflammatory cytokines on the cultured chondrocytes. He took Ph.D. in 1988, and then was appointed as an assistant professor at Kyushu University. From 1989-1992 he researched the signal transduction mechanism of IL-1 and TNF as a postdoctoral fellow at Strangeways Research Laboratory, University of Cambridge, UK. After working as an assistant professor at the Second Department of Oral and Maxillofacial Surgery, Kyushu University and an associate professor at the Department of Oral and Maxillofacial Surgery, Kumamoto University School of Medicine, he moved to Fukuoka Dental College as the professor of the Section of Oral Surgery, Department of Oral and Maxillofacial Surgery in 2005. In his research career, he has investigated the mechanisms of oral cancer invasion focusing on a transcription factor NF-κB and matrix proteases in cancer cells, aiming for molecular targeting therapy and prevention against oral cancer. As clinical practice, he took charge of tumor surgery, especially reconstruction surgery using microvascular anastomosis.

 As educational activities, he gives lecturers and practices on diagnosis and treatment of various oral diseases involved in oral surgery and oral medicine, which are aimed for the better understanding of oral diseases at the molecular level from the view point of general medicine.

 In addition, at clinics, he provides wide range of treatment for oral diseases such as jaw deformity, temporomandibular joint derangement, oral and maxillofacial trauma, sport injuries, oral medical diseases, salivary gland diseases and so on.

1. Molecular mechanism of invasion and metastasis of oral squamous cell carcinoma.
2. Effects of inflammation and oxidative stress on oral carcinogenesis.
3. Molecular and cellular mechanism of oral mucosal senescence.
4. Molecular pathology and molecular targeting therapy of bisphosphonate-related osteonecrosis of the jaw.
5. Establishment of EBM for jaw deformity surgery.
6. Molecular mechanism of bone destruction and bone reproduction of the jaw.
7. Educational development for bridging between dentistry and general medicine.

Research work by IKEBE Tetsuro